【摘要】 目的 评价亲缘异基因骨髓移植 (allo -BMT)治疗慢性髓系白血病 (CML)的临床疗效。 方法2000年9月至2002年6月 ,对11例CML慢性期患者进行HLA相合亲缘allo-BMT。预处理方案 :马利兰16mg/kg+环磷酰胺120mg/kg。急性移植物抗宿主病 (GVHD)预防 :霉酚酸酯、环孢素A加短程甲氨喋呤。结果 11例患者均获供髓植入 ,中性粒细胞数大于0.5×109/L中位时间15(11～20)d ,血小板数大于20×109/L中位时间20(10～35)d。发生Ⅱ～Ⅳ度急性GVHD2例 (18.2%) ,慢性GVHD4例 (36.4 %)。移植相关死亡2例(18.2%) ,复发1例(9.1 %)。中位随访时间20(5～31)月 ,Kaplan-Meier生存曲线的2年无病生存率为 (70.7±14.3) %。 结论亲缘allo-BMT是治疗CML的有效方法 ,霉酚酸酯可安全而有效地应用于急性GVHD的预防。更多还原

【Abstract】 Objective To evaluate the clinical efficacy of allogeneic bone marrowtransplantation(allo-BMT)fromsibling donor in treatment of chronic myeloid leukemia(CML).Methods Eleven patients with CML received allo-BMTfrom HLA-identical sibling donor.Conditioning regimen consisted of Bu16mg/kg+CTX120mg/kg.The regimen of mycophenolate mofetil(MMF),cyclosporine and methotrexate was used for prophyˉlaxis of acute graft-versus-host-disease(GVHD).Results The median follow-up period was20(5～31)months;all patients achieved complete engraftment.The median period to gain absolute neutrophil count>0.5×10 9 /L was15(11～20)d and that for platelet count>20×10 9 /L without transfusion was20(10～35)d.The incidence of acute GVHD gradeⅡ-Ⅳwas18.2%and that of chronic GVHD was36.4%.Transplant_ related mortality occurred in18.2%of the cases,recurrence of leukemia occurred in9.1%of the cases.The rate of disease free survival(DFS)at2-year was(70.7±14.3)%.Conclusion Allo-BMTfrom sibling donor is an effective method for the treatment of CML,MMF can be used effectively and safely for prevention of acute GVHD.更多还原