【摘要】 目的　观察中药保元汤加减煎剂对卡氏肺孢子虫肺炎模型大鼠免疫状态的调节作用 ,以探索中医药治疗卡氏肺孢子虫肺炎的新途径。　方法　在造模不同时间 ,以保元汤加减煎剂给卡氏肺孢子虫肺炎 (PCP)模型大鼠灌胃 ,2ml/次 ,1次 /d ,于造模后第 8周末 ,测定各组实验大鼠淋巴细胞转化率及T细胞亚群百分率。　结果　预防组大鼠淋巴细胞转化率明显高于PCP模型对照组 ,其值与正常对照组差异无显著性 ;预防组和治疗组大鼠的CD4+ 及CD4+ /CD8+ 值高于PCP模型对照组和治疗对照组 ,预防组CD4+ 及CD4+ /CD8+ 值与正常对照组差异无显著性。　结论　保元汤加减煎剂 ,可提高卡氏肺孢子虫肺炎模型大鼠的机体免疫功能 ,可作为防治卡氏肺孢虫子肺炎的药物。更多还原

【Abstract】 Objective To observe the immunological regulation of Chinese medicine Add-subtract Baoyuantang in Pneumocystis carinii pneumonia（PCP） model rats, so as to explore a new way in the treatment of PCP with Chinese medicine. Methods To establish PCP model rats and administrate Add-subtract Baoyuantang to the rats, 2 ml/time, 1 time/day. The lymphocyte transformation （LT） and the percentage of T cell subgroup of each group of rats were detected in different time after the provision. Results The LT of preventive group and treated group was significantly higher than that of the model control group. The LT of preventive group was almost the same with that of the normal control group. CD₄ +, CD₄ +/CD₈ + ratio of preventive and treated groups were higher than that of PCP model control group and treatment control group. CD₄ + of preventive group was almost the same as that of normal control group. Conclusion Add-subtract Baoyuantang can improve the immunological condition of bodies, and could be a choice in the treatment of PCP.更多还原