【摘要】 目的　探讨青年和绝经女性乳腺癌血管内皮生长因子 (VEGF)及其受体 (FLK 1)和碱性成纤维细胞生长因子 (bFGF)及其受体 (FLG)的表达特征和差异。方法　以SABC免疫组化法检测 4 0例年龄≤ 35岁的青年女性 (青年组 )和 30例绝经女性 (绝经组 )乳腺癌组织中VEGF、FLK 1、bFGF和FLG的阳性系数值并进行比较 ,探讨其与腋窝淋巴结转移和临床病理特征之间的关系 ,同时比较两组之间各项临床指标的差异。结果　青年组腋窝淋巴结转移率和VEGF、bFGF阳性系数值明显高于绝经组 ,差异有显著性或极显著性 (P <0 .0 5或P <0 .0 1) ;腋窝淋巴结转移组的VEGF、bFGF、FLK 1和FLG阳性系数值明显高于腋窝淋巴结未转移组 ,差异有显著性或极显著性 (P <0 .0 5或P <0 .0 1) ;VEGF、FLK 1和FLG阳性系数值在两组的TNM临床分期 0～Ⅱ期和Ⅲ～Ⅳ期组间差异有显著性或极显著性 (P <0 .0 5或P <0 .0 1)。结论　青年乳腺癌侵袭性强与肿瘤血管生成相关 ,主要表现为VEGF和bFGF高表达。更多还原

【Abstract】 Objective To study the difference in the expression of VEGF, bFGF and their receptors between young and postmenopausal women with breast cancer. Methods The expression of VEGF, FLK 1, bFGF and FLG in 40 young and 30 postmenopausal women with breast cancer was studied by immunohistochemical method (SABC), with its relation with axillary lymph node metastasis and the clinical and pathologic characteristics. The expression index between these two groups was compared. Results The positive axillary lymph node rate and the mean expression of VEGF, bFGF in the young group were higher than postmenopausal group ( P <0.01 and P <0.05), respectively. The mean expression of VEGF, bFGF, FLK 1 and FLG of axillary lymph node positive patients was higher than the negative ones both in young and postmenopausal women groups ( P < 0.05 and P <0.01). There was also a significant difference in VEGF, bFGF, FLK 1, FLG and MVC between the stage 0～Ⅱ and stage Ⅲ～Ⅳ( P <0.05 and P <0.01) in both groups. Conclusion Breast cancer angiogenesis, characterized by the high expression of VEGF and bFGF, is directly correlated with the high tumor aggressiveness in the young women.更多还原