【摘要】 目的　通过不同级别医院剖宫产患者预防性应用抗生素对比分析 ,旨在根据本底资料 ,进行干预。方法　回顾性调查一所二级甲等综合医院、一所三级甲等综合医院 2 0 0 1年 7月～ 2 0 0 2年 6月出院的剖宫产手术患者及分娩的新生儿预防性应用抗生素情况 ,两所医院剖宫产患者分别为 12 1例、183例 ,总共 30 4例。结果　术前 <2h、手术当日、术前 >1d抗生素应用构成比二级甲等综合性医院为 2 0 .0 %、4 3.3%、36 .7% ,三级合格综合性医院为 17.8%、5 1.1%、31.1% ;术后预防性应用抗生素≤ 3d、≤ 7d、≥ 8d构成比二级甲等医院为8 3%、76 0 %、15 .7% ,三级合格医院为 2 7.3%、71.6 %、1.1% ;术后用药天数二级甲等医院为 (5 .74± 2 .0 0 )d ,占术后住院天数的 (76 .31± 2 0 .75 ) % ,三级合格医院为 (4.17± 1.10 )d ,占术后住院天数的 (5 5 .6 6± 15 .4 0 ) % ;新生儿预防性应用抗生素率二级甲等医院为 12 .9% ,应用天数为 (3.75± 2 .94 )d ,三级合格医院预防性应用抗生素率为 10 0 0 % ,应用天数为 (3.0 6± 0 .30 )d。结论　两所医院预防用药有所不同 ,但都存在围手术期用药意识淡薄、不讲究合理性问题 ,同时新生儿预防用药有滥用现象 ,医院感染管理工作者应进行干预。更多还原

【Abstract】 OBJECTIVE To compare and analyse the states of application of preventive antibiotics in surgical patients in different category hospitals. METHODS Three hundred and four patients with cesarean section and newborns from July 2001 to June 2002 in the two hospital were investigated. RESULTS No more than 2 hours before operation, the day of surgery and less than one day after operation, the percentage of used antibiotics are 20.0%, 43.3% and 36.7% in a Grade 2A hospital, 17.8%, 51.1% and 31.1% in a Grade 3 qualified hospital, respectively; no more than three days, no more than seven days and less than eight days after operation, the percentage of used antibiotics are 8.3%, 76.0% and 15.7% in a Grade 2A hospital, 27.3%, 71.60% and 1.1% in a Grade 3 qualified hospital, respectively. The number of average days of used antibiotics after surgery are 5.74±2 00 days in a Grade 2A hospital and 4.17 ±1.10 days in a Grade 3 qualified hospital, which is about 76.31±20 75% and 55.66±15.40% of the number of average days of hospitalization after surgery. The percentage of antibiotic preventively used to the newborns is 12.9% in a Grade 2A hospital, 100% in a Grade 3 qualified hospital, the number of average days of used drug are 3.06±0.30 d in the former hospital, and 4.17±1.10 d in the letter qualified hospital. CONCLUSIONS There is a little difference in the application of preventive antibiotics between the two hospitals. The study result shows that the medical staffs mentioned above lack the knowledge about the drug use during period of operation. In the same time, the current situation of drug abuse to newborns is very serious in some hospitals. As this result, the directorship of hospital should carry out measures immediately to improve the situation of drug abuse.更多还原