【摘要】 目的　探讨温州地区原发性肝癌危险因素的病因分值及乙型肝炎病毒表面抗原(HBsAg)阳性与其他各危险因素间的交互效应。方法　对温州地区 180例原发性肝癌患者进行了 1∶1配对病例对照研究 ,在Mantel Haenszel分层分析和条件logstic回归的基础上 ,分析了原发性肝癌危险因素的病因分值及HBsAg阳性与其他各危险因素间的交互效应。结果　HBsAg阳性、5年前不良经济、喜食腌菜、一级亲属肝癌家族史及负性生活事件为肝癌的危险因素 ,病因分值分别为 0 72 8、0 2 4 5、0 2 2 4、0 0 84和 0 2 34。HBsAg阳性与 5年前不良经济、喜食腌菜、一级亲属肝癌家族史、负性生活事件间交互作用 ,其病因分值为 0 770、0 6 30、0 84 8和 0 6 2 7。交互指数为 0 789、0 6 38、0 85 2和0 6 34。结论　HBsAg阳性、5年前不良经济、喜食腌菜、一级亲属肝癌家族史、负性生活事件可能为温州地区原发性肝癌重要的危险因素 ;HBsAg阳性与 5年前不良经济、喜食腌菜、一级亲属肝癌家族史及负性生活事件并存时 ,能增加肝癌的危险性。更多还原

【Abstract】 Objective To explore etiologic fraction (EF) and interaction of serum hepatitis B surface antigem (HBsAg) carriage and other risk factors for primary hepatocellular carcinoma (PHC) in Wenzhou, Zhejiang, China. Methods 1∶1 matched case-control study was carried out in Wenzhou, with 180 cases of PHC and 180 controls.EF and interactions of serum positive HBsAg [HBsAg (+)] and other risk factors for PHC were analyzed by Mantel-Haenszel stratified method and conditional multiple logistic regression.Results Serum HBsAg (+), poor economic status during the past five years, preferring intake of pickled vegetables, history of PHC in their first-degree relatives, and negative life events all were risk factors for PHC, with EFs of 0.728, 0.245, 0.224, 0.084, and 0.234, respectively.There existed interactions of HBsAg (+) with other risk factors, including poor economic status during the past five years, preferring intake of pickled vegetables, history of PHC in their first-degree relatives, and negative life events, with etiologic fractions attributable to interaction [EF (A×B) ] of 0.770, 0.630, 0.848, and 0.627, and indices of interaction of 0.789, 0.638, 0.852, and 0.634, respectively.Conclusions Main risk factor for PHC in Wenzhou, Zhejiang, China could include HBsAg (+), poor economic status during the past five years, preferring intake of pickled vegetables, history of PHC in their first-degree relatives, and negative life events.HBsAg (+) plus any of the following factors, such as poor economic status during the past five years, preferring intake of pickled vegetables, history of PHC in their first-degree relatives, and negative life events, could increase the risk of PHC.更多还原