【摘要】 目的　探讨在重庆市区生活 10年以上的汉族绝经妇女骨质疏松症与维生素D受体基因多态性的关系。方法　用聚合酶链反应 限制性片段长度多态性技术检测了 40例绝经后患骨质疏松症的妇女和 2 1名同龄绝经后无骨质疏松症的妇女的维生素D受体基因多态性。结果　骨质疏松组维生素D受体基因型bb、Bb、BB频率分别为 82 .5 %、17.5 %及 0 ,无骨质疏松组分别为 85 .71%、14 .2 9%及 0 ,两组差异无显著性 (P >0 .0 5 )。结论　就目前调查例数看 ,重庆地区汉族妇女骨质疏松与BB基因型无明显相关性。更多还原

【Abstract】 Objective To determine the relationship between vitamin D receptor (VDR) gene polymorphism and osteoporosis in postmenopausal women.Methods The polymerase chain reaction restriction fragment length polymorphism was used to detect VDR genotype in 40 patients with osteoporosis and 21 healthy postmenopausal women.Results In the patients with osteoporosis, the bb, Bb, and BB genotype accounted for 82.5%, 17.5% and 0, respectively; in healthy groups, they were 85.71%, 14 29% and 0, respectively( P>0.05). Conclusion Significant association between VDR genotype and osteoporosis in Chinese women was observed in this study.更多还原