【摘要】 目的　调查 GSTT1,GSTM1纯合缺失基因型频率在云南民族群体和地理上的分布。方法采用聚合酶链式反应的方法 ,对云南省 11个地区 2 4个民族群体进行 GSTT1,GSTM1基因型分析。结果GSTT1和 GSTM1纯合缺失基因型频率在民族间的分布分别为 0 .188～ 0 .6 33、0 .4 0 0～ 0 .74 5 ,地区间分布分别为 0 .2 86～ 0 .5 83、0 .4 33～ 0 .74 5 ;基因频率与民族差异在 GSTT1基因中存在统计学上的显著关系 ,而在 GSTM1中无显著关系。基因频率与地区差异在统计学上无显著关系。结论　 GSTT1,GSTM1纯合缺失基因型频率在云南各民族群体中存在差异 ,但在地区分布上比较均一。更多还原

【Abstract】 Objective To investigate the frequencies distribution of GSTT1 and GSTM1 null genotypes in 24 Yunnan populations. Methods GSTT1 and GSTM1 genotypes were analyzed by PCR procedure. Results The range of frequencies for GSTT1 and GSTM1 null genotypes in the populations were 0.188 0.633 and 0.400 0.745, respectively, and in the districts were 0.286 0.583, 0.433 0.745 respectively. There was significant relationship between GSTT1 frequencies and populations. Conclusion The frequencies of GSTT1 and GSTM1 null genotypes in 24 Yunnan populations were different, but they were almost the same in different districts of Yunnan.更多还原