【摘要】 目的　比较丹参、川芎嗪、硫酸镁对妊娠高血压综合征 (简称妊高征 )患者治疗后血中超氧化物歧化酶 (superoxidedismutase,SOD)、脂质过氧化物 (malondialdehyde ,MDA )、血栓素A2(thromboxane2 ,TXA2 )、前列环素I2 (prostaglandlinI2 ,PGI2 )、一氧化氮 (nitricoxide ,NO)、内皮素(endothelinl,ET)及母儿结局的影响。　方法　用丹参、川芎嗪、硫酸镁分别治疗中度妊高征患者各75例 ,观察三组患者治疗前与治疗后SOD、MDA、TXA2 、PGI2 、NO、ET、平均动脉压、产后出血、胎心率异常、新生儿窒息的变化情况。　结果　治疗前后三组SOD(178.3± 4 .1与 2 19.5± 4 .1、190 .4±2 .4与 2 0 8.4± 2 .4、176 .1± 3.4与 2 2 1.1± 2 .2 )mg L、MDA(11.4± 1.3与 7.2± 1.2、13 0± 2 .7与8.6± 2 0、10 .3± 1.5与 7.1± 1.1)mmol L、NO(74 7± 2 0 2与 94 0± 2 32、798± 15 9与 90 7± 14 2、776± 2 12与 86 2± 189)nmol L、ET(78.3± 4 .5与 6 2 .3± 3.8、78.3± 4 .3与 5 8.3± 4 .4、76 .9± 3.9与6 0 .2± 2 .9)ng L、TXA2 (5 6 0± 2 8与 4 86± 2 7、5 37± 2 7与 5 0 2± 2 0、5 5 8± 2 5与 4 72± 2 1) pg L、PGI2(16 2± 13与 2 17± 14、16 7± 17与 2 2 7± 16、16 9± 13与 2 13± 11)pg L更多还原

【Abstract】 Objective To determine whether therapy of Salvia miltiorrhiza,Ligustrazine and magnesium sulfate has effect on concentrations of SOD, MDA,NO,ET,TXA 2, PGI 2 in blood and outcomes of women with pregnancy-induced hypertension(PIH). Methods Two hundred and twenty-five women with moderate PIH were studied while treated with Salvia miltiorrhiza, Ligustrazine and magnesium sulfate in group A, B, and C(n=75 respectively). Concentrations of SOD, MDA, NO, ET, TXA 2, PGI 2 in blood, blood pressure, postpartum hemorrhage, fetal distress, and neonatal asphyxia were monitored. Results In maternal blood the concentrations of SOD in the three groups before and after treatment were 178.3±4.1 vs 219.5±4.1、190.4±2.4 vs 208.4± 2.4、176.1±3.4 vs 221.1±2.2、MDA 11.4±1.3 vs 7.2±1.2、13.0±2.7 vs 8.6±2.0、10.3±1.5 vs 7.1±1.1、NO 747±202 vs 940±232、798±159 vs 907±142、776±212 vs 862±189、ET 78.3±4.5 vs 62.3±3.8、78.3±4.3 vs 58.3±4.4、76.9±3.9 vs 60.2±2.9、TXA 2 560±28 vs 486±27、537±27 vs 502±20、558±25 vs 472±21、PGI 2 162±13 vs 217±14、167±17 vs 227±16、169±13 vs 213±11 respectively,there were significant differences between betore and after treatment (P<0.05). Group C(20%) had higher incidence of abnormal fetal heart rate than that of group A(9.33%) and B (10.67%)(P<0.05). No differences were found in blood pressure, the incicences of neonatal asphyxia and postpartum hemorrhage in three groups (P>0.05). Conclusions It is showed that Salvia miltiorrhiza ,Ligustrazine and magnesium sulfate can well balance circulating levels of SOD, MDA, NO, ET, TXA 2, and PGI 2 in women with PIH. Magnesium sulfate may interfere the results of the monitoring on the fetal heart rate.更多还原