【摘要】 目的　比较Amplatz血栓消融术 (Amplatzthrombectomydevice ,ATD)、溶栓 (thromboly sis,TL)及外科取栓 (thrombectomy ,TX)治疗犬急性股静脉血栓形成后静脉壁形态学变化。 方法36只成年杂种犬制作成股静脉血栓模型后随机分为 3组 ,每组 12只。另 4只假手术 ,作对照组。结果 3组均能有效地清除血栓。ATD、TL、TX组 1周静脉通畅率分别为 75 %、33%、2 5 % (P <0 0 5 )。TX组内膜增生最严重。ATD组胶原染色面积百分比较TX和TL组少 (P <0 0 1)。 1周时ATD及TL组内皮损伤较TX组轻 (P <0 0 5 )。结论ATD治疗犬急性股静脉血栓形成具有良好的近期效果。ATD及TL具有同样的内皮结构保护作用。更多还原

【Abstract】 Objective To evaluate the effects of Amplatz thrombectomy device (ATD), thrombolysis (TL), and surgical thrombectomy (TX) on venous wall morphology complicated with acute femoral vein thrombosis in dogs. Methods The femoral venous thrombosis model was induced in 36 adult mongrel dogs. The thrombosed veins were treated with ATD ( n =12), TL ( n =12), and TX ( n =12), respectively. Results Clearance of thrombus was successful in all cases. One week after treatment, the rate of venous patency in ATD, TL, and TX group was 75%, 33%, and 25%, respectively ( P <0.05). TX group experienced significant intimal hyperplasia. The percentage of collagen staining area in ATD group was less than the other two groups ( P <0.01) after treatment. The degree of endothelium injury in ATD and TL groups was minor compared with TX group in one week ( P <0.05). Conclusions ATD for the treatment of canine acute femoral vein thrombosis has both good short-term effect and satisfactory protection of the endothelium compared with TL.更多还原