【摘要】 以聚乳酸为载体 ,用溶剂挥发法制得顺铂聚乳酸微球。选择聚乙二醇浓度、油 /水相体积比、聚乳酸浓度、乳化时间、理论载药量 5个因素 ,每个因素选择 5个水平 ,用均匀设计安排实验。并以微球表面形态、粒径大小及分布、载药量、包封率为指标优化微球的制备工艺。按优化条件制得的微球算术平均径为 48.6 2 μm,载药量为 15 .1% ,包封率为 5 0 .1% ,体外释放符合一级动力学方程。更多还原

【Abstract】 Polylactic acid enveloped cisplatin microspheres (DDP-PLA-MS) were prepared by the solvent evaporation method. The uniformity design of 5 factors and 5 levels was applied to optimize the preparation procedure of with indexes of particle size, appearance, drug content, rate of encapsulation. Microspheres were obtained with the mean diameter of 48.62 μm, drug content of 15.1% and encapsulated rate of 50.1%, the release profile in vitro could be described by first-order kinetic equation.更多还原