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2型糖尿病患者外周血单个核细胞中醛糖还原酶mRNA水平与糖尿病肾病危险性的关系
Relationship between aldose reductase gene expression in peripheral blood mononuclear cells and the risk of diabetic nephropathy in type 2 diabetic patients
【摘要】 以RT PCR法检测外周血单个核细胞 (PBMC)中醛糖还原酶 (AR)mRNA水平。 2型糖尿病患者的PBMCARmRNA水平与尿白蛋白排泄率呈正相关 ,提示AR活性与糖尿病肾病的发病机制有关。
【Abstract】 Aldose reductase (AR) mRNA level in peripheral blood mononuclear cells was assayed by RT-PCR. There was a positive correlation between PBMC AR mRNA level and urinary albumin excretion rate in type 2 diabetic patients. The result suggests that AR activity is related to the pathogenesis of diabetic nephropathy.
【关键词】 醛糖还原酶;
糖尿病,非胰岛素依赖型;
糖尿病肾病;
尿白蛋白排泄率;
【Key words】 Aldose reductase; Diabetes mellitus, non-insulin dependent; Diabetic nephropathies; Urinary albumin excretion rate;
【Key words】 Aldose reductase; Diabetes mellitus, non-insulin dependent; Diabetic nephropathies; Urinary albumin excretion rate;
【基金】 浙江省教育厅科研基金资助项目 (982 0 1 3) ;浙江省卫生厅科研基金资助项目 (98A0 1 3)
- 【文献出处】 中华内分泌代谢杂志 ,Chinese Journal of Endocrinology and Metabolism , 编辑部邮箱 ,2003年06期
- 【分类号】R587.2
- 【被引频次】2
- 【下载频次】107