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尿TGF-β1、层粘连蛋白、Ⅳ型胶原与2型糖尿病肾病的关系
Association of urinary transforming growth factor- β1, laminin and type Ⅳ collagen with diabetic nephropathy in type 2 diabetic patients
【摘要】 在 18 2例 2型糖尿病患者测定尿液转化生长因子β1(TGF β1)、层粘连蛋白 (LN)和Ⅳ型胶原排泄量 ,糖尿病患者的尿液TGF β1、LN和Ⅳ型胶原排泄量增加 ,并与糖尿病肾病 (DN)的严重程度有较好的相关性。尿TGF β1可能为早期DN的指标、尿LN、Ⅳ型胶原可能为DN严重程度的指标
【Abstract】 Urinary excretions of transforming grow th factor-β 1 (TGF-β 1), laminin (LN) and type Ⅳ collagen were determined i n 182 type 2 diabetic patients. Urinary excretions of TGF-β 1, LN and type Ⅳ collagen were increased in type 2 diabetic patients, and these findings were fa irly well correlated with severity of diabetic nephropathy (DN). Urinary TGF-β 1 seems to be the early index of DN, urinary LN and type Ⅳ collagen appear to be the indices of DN severity.
- 【文献出处】 中华内分泌代谢杂志 ,Chinese Journal of Endocrinology and Metabolism , 编辑部邮箱 ,2003年05期
- 【分类号】R587.1
- 【被引频次】8
- 【下载频次】165