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尿TGF-β1、层粘连蛋白、Ⅳ型胶原与2型糖尿病肾病的关系

Association of urinary transforming growth factor- β1, laminin and type Ⅳ collagen with diabetic nephropathy in type 2 diabetic patients

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【作者】 冯文焕高鑫叶真汪大望郑景晨陶志华吴建波沈飞霞

【Author】 FENG Wen-huan *, GAO Xin, YE Zhen, WANG Da -wang, ZHENG Jing-chen, TAO Zhi-hua, WU Jian-bo, SHEN Fei-xia. *Departmen t of Endocrinology, The First Hospital Affiliated to Wenzhou Medical College, We nzhou 325000 Corresponding author: GAO Xin, Department of Endocrinology, Zhongshan Hospital, Fudan University, Shanghai 200032

【机构】 温州医学院附属第一医院内分泌科上海复旦大学附属中山医院内分泌科温州医学院附属第一医院检验科温州医学院附属第一医院医科所温州医学院附属第一医院内分泌科 325000325000

【摘要】 在 18 2例 2型糖尿病患者测定尿液转化生长因子β1(TGF β1)、层粘连蛋白 (LN)和Ⅳ型胶原排泄量 ,糖尿病患者的尿液TGF β1、LN和Ⅳ型胶原排泄量增加 ,并与糖尿病肾病 (DN)的严重程度有较好的相关性。尿TGF β1可能为早期DN的指标、尿LN、Ⅳ型胶原可能为DN严重程度的指标

【Abstract】 Urinary excretions of transforming grow th factor-β 1 (TGF-β 1), laminin (LN) and type Ⅳ collagen were determined i n 182 type 2 diabetic patients. Urinary excretions of TGF-β 1, LN and type Ⅳ collagen were increased in type 2 diabetic patients, and these findings were fa irly well correlated with severity of diabetic nephropathy (DN). Urinary TGF-β 1 seems to be the early index of DN, urinary LN and type Ⅳ collagen appear to be the indices of DN severity.

  • 【文献出处】 中华内分泌代谢杂志 ,Chinese Journal of Endocrinology and Metabolism , 编辑部邮箱 ,2003年05期
  • 【分类号】R587.1
  • 【被引频次】8
  • 【下载频次】165
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