节点文献

2型糖尿病患者急性时相蛋白与糖尿病肾病的关系

Relationship between serum acute-phase proteins and diabetic nephropathy in type 2 diabetic patients

  • 推荐 CAJ下载
  • PDF下载
  • 不支持迅雷等下载工具,请取消加速工具后下载。

【作者】 何冰韩萍吕先科

【Author】 HE Bing, HAN Ping, LU Xian-ke. Department of Endocrinology, The Second Hospital Affiliated to China Medical University, Shenyang 110004

【机构】 中国医科大学附属第二医院内分泌科中国医科大学附属第二医院内分泌科 110004沈阳110004沈阳

【摘要】 目的 探讨糖尿病肾病不同时期血清急性时相蛋白浓度的变化及其意义。方法 正常对照组 3 0例和 2型糖尿病组 10 0例进入本研究 ,根据尿白蛋白排泄率 (UAER )将糖尿病患者分为正常蛋白尿组 ( 3 9例 )、微量白蛋白尿组 ( 3 0例 )和临床蛋白尿组 ( 3 1例 )。采用数率散射比浊法测定血清C反应蛋白、α1 酸性糖蛋白 (α1 AAG)、铜蓝蛋白 (CER)浓度 ,用快速比色法测定唾液酸 (SA )。结果  ( 1) 2型糖尿病患者血清急性时相蛋白浓度较对照组明显升高。 ( 2 )急性时相蛋白浓度随UAER的增加而增加。 ( 3 )多元逐步回归分析表明部分急性时相蛋白 (α1 AAG ,CER ,SA)与甘油三酯及胆固醇相关。结论  2型糖尿病患者中存在急性时相反应 ,而且急性时相反应的强度与糖尿病肾病的程度存在一致性。

【Abstract】 Objective To investigate the levels of serum acute phase protein in different stages of diabetic nephropathy and their implication. Methods This study included 30 healthy subjects and 100 patients with type 2 diabetes mellitus, diabetic patients were further divided into three subgroups according to their urinary albumin excretion rate (UAER): 39 patients with normal UAER, 30 patients with microalbuminuria and 31 patients with clinical proteinuria. C-reactive protein, α 1-acid glycoprotein (α 1-AAG), ceruloplasmin (CER) were measured with rate nephelometry method, sialic acid was measured with MTT method. Results (1) Acute phase protein concentrations were significantly higher in patients of type 2 diabetes mellitus than those in normal controls. (2) Acute phase protein concentrations were increased with increment of UAER. (3) Some acute phase proteins (α 1-AAG, CER and SA) were correlated with serum cholesterol and triglyceride independently. Conclusion There is acute phase reaction in type 2 diabetes mellitus and the degree of acute phase reaction is correlated with the degree of diabetic nephropathy.

  • 【文献出处】 中华内分泌代谢杂志 ,Chinese Journal of Endocrinology and Metabolism , 编辑部邮箱 ,2003年04期
  • 【分类号】R587.1
  • 【被引频次】225
  • 【下载频次】372
节点文献中: 

本文链接的文献网络图示:

本文的引文网络