【摘要】 目的 比较鞘内注射孤啡肽在Swiss albino和C57 BL两种小鼠中所引发的痛觉超敏的特点。方法 以随机、双盲、画笔轻触法,观察鞘内注射孤啡肽50 min内两种小鼠痛觉超敏反应。结果 在Swiss albino小鼠中,孤啡肽引起的痛觉超敏持续50 min,在5 fmol～50 pmol的剂量范围内,没有观察到量效关系。在C57 BL小鼠中,孤啡肽引起的痛觉超敏持续30 min,在10fmol～1nmol的剂量范围内,呈现出钟形的量效曲线。结论 鞘内注射孤啡肽的作用有小鼠种系间的区别。更多还原

【Abstract】 Objective To compare the allodynic effect of intrathecal nociceptin between Swiss albino and C57 BL mice. Methods The allodynic effect was evaluated by allodynic scores by light touching using paintbrush. The allodynic effect of intrathecal nociceptin was observed over 50 min after injection in two mouse strains in a double blind manner. Results The allodynia induced by nociceptin lasted for 50 min in Swiss albino and no dose-response relationship was observed from dose 5 fmol- 50 pmol per mouse. In C57 BL mice, allodynic effect lasted for 30 min and showed a bell-shaped dose-response curve from dose 10 frnol-1 nmol per mouse. Conclusion These results demonstrate that the allodynic eflect of intrathecal nociceptin is different between strains.更多还原