【摘要】 目的　研究局部使用维拉帕米对大鼠缺血随意型皮瓣的作用。方法　建立大鼠背部缺血随意型皮瓣的动物模型 (长∶宽 =6∶1) ,术后在皮瓣下一次性注射维拉帕米 5mg ,术后 7d取材 ,测定皮瓣坏死率和中段组织中丙二醛含量 ,并进行标本大体观察及病理切片观察。结果　维拉帕米组皮瓣坏死率 15.9% ,中段组织中丙二醛含量为 164.8nmol/L。对照组皮瓣坏死率为 2 1.8% ,丙二醛含量为19 5.8nmol/L。两组比较差异具有显著性意义。光镜下 ,实验组的炎性反应较对照组明显减轻。结论　维拉帕米能提高缺血随意皮瓣的成活率 ,且大剂量一次性给药的方法具有可行性更多还原

【Abstract】 ObjectiveTo investigate the effect of verapamil on the i schemic random skin flaps. MethodsThe dorsal random skin flap s of Wistar rats were raised (length/width=6/1). Verapamil was injected under th e flaps at the dose of 25mg/kg after the operations. Seven days later, the necro sis rate, the content of molondialehyde (MDA) in middle segment and the microsco pic observation were studied. ResultsThe necrosis rates were 1 5.9 % in verapamil group and 21.8 % in control group. The content of MDA in midd le segment of verapamil group was 164.8 nmol/L, and that in control group was 19 5.8 nmol/L. The difference was very significant. Under the microscope, the tissu e inflammatory reactions in the experiment group were not so severe as that in t he control group. ConclusionVerapamil improves the survival of the ischemic random skin flaps and it is applicable to give verapamil by subcut aneous injection.更多还原