【摘要】 目的　了解肉毒素除皱后的不良反应。方法　观察除皱者注射肉毒素后临床表现。结果　 12 1例使用肉毒素除皱者 ,注射后无全身不良反应 ;有些不良反应是由肌肉松弛引起的 ,如除额纹时提眉功能减弱、除下眼睑纹时睑袋加重等。美容除皱者动力性皱纹消退有差异 ,部分除皱者动力性皱纹消退两侧不一致 ,沟状深纹除皱后仍见痕迹 ,多数不良反应持续 1～ 2周 ,皱纹复现在注射后 3～ 7个月。结论　肉毒素除皱安全 ,不良反应短暂、限于局部并较轻微 ,除皱效果不持久更多还原

【Abstract】 Objective To study the adverse reaction of botulinum A t oxin (BTXA) treatment for wrinkles. Methods The adverse r eactions were observed after injection of BTXA. Results No serious or general adverse reactions occurred. As wrinkle eliminated with muscle s relaxing, and muscles relaxation could result in some adverse reactions such a s brow movement weakness. When forehead wrinkles were eliminated baggy blepharop tosis became more serious. Some symmetry wrinkles in two side of face could not equally eliminated. After administration of botulinum A toxin treatment, the wri nkle-like groove could be improved significantly but the groove still remained. The adverse reaction often continued for 1～2 weeks, and the wrinkle recurred 3 ～ 7 months after the botulinum A toxin treatment. Conclusion U sing botulinum A toxin to treat wrinkle is safe and effective, and the adverse reaction is local, slight and transient.更多还原