【摘要】 目的　对血管紧张素原 (AGT)基因第二外显子M2 35T多态性与原发性高血压的关联性进行Meta分析。方法　以原发性高血压组和健康对照组基因型分布的OR值为统计量。全面检索相关文献 ,剔除不符合要求的文献 ,应用REVMAN 4 .1软件对各研究结果进行一致性检验和数据合并 ,并评估发表偏倚的影响。结果　 10篇文献无明显异质性。共包括原发性高血压组患者 85 3例 ,健康对照组 835名 ,合并TT/ (MT +MM )OR =1.76 ,95 %CI :1.4 4～ 2 .16 ,P <0 .0 0 0 0 1,T/MOR =1.5 4 ,95 %CI:1.31～ 1.81,P <0 .0 0 0 0 1。结论　中国人 (汉族为主 )AGTM2 35T多态性的T等位基因和TT基因型与原发性高血压危险性增加有关联。更多还原

【Abstract】 Objective To study on the association of M235T polymorphism of the angiotensinogen gene extron 2 (AGT/M235T) and essential hypertension (EH) in Chinese population by means of Meta-analysis. Methods Odds ratios ( OR ) of AGT M235T genotype distributions in EH patients against healthy controls were analyzed. All the relevant studies were identified, poor-qualified studies eliminated, and the risk of publication bias excluded. The Meta-analysis software, REVMAN 4.1 , was applied for investigating heterogeneity among individual studies and summarizing the effects across studies. Results A total of 853 cases and 835 controls from 10 studies were included. No heterogeneity among the studies was noticed. The frequencies of the AGT TT, MT and MM genotypes were 65%, 30%, and 4.9 % in cases and 50.6 %, 41.8 % and 7.5 % in controls respectively. The frequencies of the AGT T allele were 80% in cases and 72% in controls. The pooled OR (with 95% CI ) of TT vs MT+MM was 1.76 ( 1.44- 2.16 )( P < 0.000 01 ) with T vs M 1.54 ( 1.31- 1.81 ). The pooled OR of MM vs MT+ TT was 0.67 ( 0.45- 1.00 )( P = 0.05 ). Conclusion In Chinese population (mainly the Hans), TT genotype might be associated with the increased risk of EH while MM genotype be associated with low risk of EH.更多还原