【摘要】 目的　探讨13 C 尿素呼气试验 (UBT)对消化道内镜活组织检查幽门螺杆菌 (Hp)漏检患者的价值。方法　以13 C UBT检测Hp阳性、血清学酶联免疫吸附测定 (ELISA)Hp IgG阳性而消化道内镜活组织检查呈阴性的患者 2 7例 ,为消化道内镜活组织检查假阴性的可疑对象。行 2次13 C UBT检查 ,均为阳性者 ,临床抗菌治疗 ,再次查13 C UBT。比较 3次检测值的变化。结果　 2 7例患者13 C UBT第 1次检测值为 2 1 984± 11 42 9,第 2次为 2 1 967± 11 3 0 4,两者差异无显著性 (P >0 0 5) ,抗菌治疗后第 3次检测值为 1 2 54± 1 3 4 1,与第 1次比较差异有显著性 (P <0 0 1)。结论　13 C UBT结合消化道内镜活组织检查可有效提高Hp感染的检出率更多还原

【Abstract】 Objective To explore the value of 13 C-urea breath test (UBT) as a compl ementary detecting method when the helicobacter pylori (Hp) biopsy of digest ive end oscopy yields a misdetection. Methods In the routine 13 C-UBT, 27 patients with negative Hp biopsy and positive enzyme linked imm unoadsorbent assay (ELISA) results were fo und with positive 13 C-UBT. These 27 patients were assumed to be t he suspectable false negative cases of Hp biopsy and then were enrolled in t his study. 13 C-UBT was repeated in these 27 patients. If the results of the second 13 C-UBT were still positive, the patients then rece ived a period of clinical antibiotic treatment. After that, 13 C-U BT was done for the third time. Difference was analyzed with the paired sample t-test. Results The mean value of the first and second 13 C-UBT in these 27 patients was 21.984±11.429 (the first study) and 2 1.967±11.304 (the second study), respectively. Difference was not significant b etween these two studies (P>0.05). The mean value of the third 13 C-UBT after a period of antibiotic treatment was 1.254±1 341 (the third st u dy). Difference was significant between the first and the third 13 C-UBT (P<0.01). Conclusion Hp biopsy combining with 13 C-UBT can effectively reduce the misdetection of Hp biopsy and im prove the detection rate of Hp infection.更多还原