【摘要】 目的　探讨气管癌、支气管肺癌腔内放射治疗的价值。方法　 4例原发气管癌和 2 2例原发支气管肺癌及 14例 (18处病变 )支气管肺癌术后复发者 ,外放射采用 6MVX射线 ,剂量为DT30～77Gy(平均 5 2Gy) ;腔内照射采用低剂量率192 Ir小线源 (1.4 8BGq) ,支气管黏膜参考点剂量为4～ 6Gy/次 ,总剂量 10～ 5 3Gy(中位值 2 8Gy)。结果　 37例肿瘤完全消退 (CR) ,2例部分消退 (PR) ,1例轻微变化 (MR) ,3、5年局部控制率分别为 75 %和 6 5 %。 2 3例生存时间≥ 3年 ,3年生存率为5 7.5 %。并发症较少见。结论　外放射结合腔内照射治疗对于早期支气管肺癌、局限性气管癌和支气管肺癌术后复发者是有效的治疗手段 ,长期生存是可能的。更多还原

【Abstract】 Objective To discuss the role of combined external beam radiotherapy and intraluminal brachytherapy for tracheal cancer and bronchogenic carcinoma. Methods From February 1987 to August 1996, 4 patients with primary tracheal cancer, 22 with primary lung cancer and 14 (18 sites) with postoperative recurrent lung cancer were irradiated. External beam radiotherapy (EBR ) was delivered with linac X-ray to a total dose of 30-77?Gy (median 52?Gy). Intraluminal irradiation (IR ) was delivered with low dose rate 192 Ir (1.48?BGq) to a total dose of 10-53?Gy (median 28?Gy), 4-6?Gy per fraction on the bronchial mucosa. Results Complete response (CR) was obtained in 37 patients, partial response (PR) in 2 and minor response (MR) in 1. The 3-year and 5-year local control rates by Kaplan-Meier method were 75% and 65%. Twenty-three patients have survived for 3 years or longer, with a 3-year survival rate of 57.5%. Complications were rare. Conclusions Combined external beam radiotherapy and intraluminal irradiation is effective for primary lung cancer and localized tracheal cancer, possibly giving long-term survivals.更多还原