【摘要】 目的　探讨复发性卵巢上皮性癌 (卵巢癌 )再次应用铂类药物进行化学药物治疗 (化疗 )的近期疗效及其相关因素。方法　 1998年 1月～ 2 0 0 2年 10月收治对铂类药物敏感的卵巢癌患者 4 1例 ,回顾性分析 4 1例复发后再次应用铂类药物化疗的近期疗效 ,并选择年龄、初次手术结果、化疗疗程数、化疗是否规范、血清CA12 5水平、是否随访、复发间隔时间、复发部位及复发病灶数等 37个因素进行疗效分析。结果　再次应用铂类药物的近期有效率为 5 6 % ,无严重毒副反应 ;疗效与复发后化疗是否规范有显著相关性 (r=0 92 ,P <0 0 5 ) ,其中规范化疗的近期有效率为 76 % (19/ 2 5 ) ,不规范化疗为 2 5 % (4/ 16 )。近期有效率与其他因素无显著相关性 (P >0 0 5 )。结论　对铂类药物敏感的复发性卵巢癌患者可再次应用铂类药物化疗 ,其近期疗效与复发后是否规范化疗有关。更多还原

【Abstract】 Objective To analysis the related factors of efficacy of re-platinum chemotherapy in platinum-sensitive recurrent ovarian carcinoma. Methods Forty-one patients with platinum-sensitive recurrent ovarian cancer from Jan.1998 to Oct.2002 were reviewed,37 factors were analyzed,including age,the optimal of primary surgery,number of chemotherapy cycles,standard chemotherapy or not,serum CA 125 level,follow up or not,relapse interval,the site and the number of relapse lesion,et al. Results Response rate of chemotherapy was 56%,the toxicity was not serious .Response rate of standard chemotherapy was 76%(19/25),not standard chemotherapy was 25%(4/16),standard chemotherapy or not was the only factor related to efficacy( P <0.05).Conclusion Re-platinum chemotherapy to platinum-sensitive recurrent ovarian carcinoma is reasonable,standard chemotherapy or not affects the response rate.更多还原