【摘要】 目的　探讨控释前列腺素E2 栓剂———普贝生用于足月引产的有效性及安全性。方法　采用多中心、前瞻性、病例对照研究的方法 ,对 10 0例孕周超过 37周、无严重合并症的初产妇 ,以阴道放置含普贝生的可复性装置引产作为研究组 ;另选 4 9例同样条件 ,阴道内放置不含普贝生的可复性装置的初产妇作为对照组。比较两组产妇的Bishop评分、临产情况及分娩的发生时间、剖宫产率、对胎儿及新生儿的影响。结果　研究组产妇给药后Bishop评分 ,93例提高≥ 2分 ,而对照组仅 2例提高≥ 2分 ,两组比较 ,差异有极显著性 (P <0 0 1)。研究组从给药到分娩的时间为 (14 5 2± 1190 )min ,对照组为 (4 5 0 2± 2 90 7)min ,两组比较 ,差异有极显著性 (P <0 0 1)。研究组的剖宫产率为 32 % ,而对照组则为 6 1%。两组产妇产程中的胎心变化、羊水异常发生率无明显差异 ;两组新生儿出生时状况无明显差异。宫缩过度刺激是普贝生的主要副作用 ,但研究组的发生率仅 3% ,取药后即可好转 ,并有 2 %的病例有轻度胃肠道反应。结论　普贝生可安全、有效地用于足月引产。更多还原

【Abstract】 Objective To explore the efficacy and safety of continuously released prostaglandin E₂ （PGE₂） suppository-propess used for induction of term pregnancy. Methods A multicenter,prospective, case control clinical study was carried out, propess was used in 100 cases as study group, the suppository without PGE₂ was used in 49 cases as control group. The cervical maturity（by Bishop scoring）,the time to labor starting, membrane rupture and delivery, the application of oxytocin, ceserean section rate, fetal and neonatal condition were compared between 2 groups after inserting of the suppository. At the same time, side effects caused by propess were investigated. Results Bishop score was increased ≥2points in 93% cases, ≥3points in 87% cases in study group, whereas only 4% cases whose Bishop score increased ≥2points in control group. The time to labor starting, membrene ruprute, and delivery was shortned obviously in study group than that in control group after inserting suppository. The application of oxytocin was much less in study group, cesarean section rate was reduced in study group （32% vs 61%）. There was no significant difference between 2 groups in fetal and neonatal conditions. The overstimulation of uterine contraction and mild gastriontes tinal tract reaction occurred in 3 cases and 2 cases respectively in study groups. Conclusion Propess can be used for induction of term pregnancy effectively and safely.更多还原