【摘要】 目的　探讨突发性聋伴高脂血症患者血浆P选择素、血小板、蛋白激酶C( proteinkinaseC ,PKC)、脂蛋白 (a) [lipoproten(a) ,Lp(a) ]、血清一氧化氮 (NO)水平变化及降脂干预的价值。 方法　60例患者 ,分为试验组和对照组 (各 30例 ) ,对照组采用高压氧及扩血管剂治疗 ,试验组加用降脂药物。采用双位点双抗夹心法测定Lp(a) ,酶标多克隆抗体夹心法测定P选择素 ,硝酸还原酶比色法测定NO ,双试剂免疫比浊法测定血脂 ,血细胞分析仪测定血小板。另选 30名健康者作为健康对照组。结果　治疗后听力恢复试验组治愈 1 8耳 ,显效 9耳 ,有效 6耳 ,无效 5耳。对照组治愈 7耳 ,显效 1 1耳 ,有效 1 0耳 ,无效 1 3耳。两组比较 ,差异存在显著性 ( χ2 =3 86,P <0 0 5 )。血液检测表明 :试验组血小板、Lp(a)、膜性PKC(membranousPKC ,M PKC)、P选择素、NO治疗前与健康组比较 ,差异存在显著性 ;治疗后比较 ,差异无显著性。试验组治疗前后比较 ,差异存在显著性。对照组血小板、Lp(a)、M PKC、P选择素、NO治疗前、后与健康组比较 ,差异均有显著性。对照组治疗前后比较 ,差异无显著性。试验组血小板、Lp(a)、M PKC、P选择素、NO治疗前与对照组比较 ,差异无显著性 ;治疗后比较 ,差异存在显著性。结论　通过降脂干预 ,能够有效地更多还原

【Abstract】 Objective To observe the change of plasma P selectin, platelet (PLT), protein kinase C(PKC), lipoprotein (a) and serum NO, and the effect of decreasing blood grease on the patients with sudden deafness partnering with hyperlipemia Methods Sixty cases were divided randomly into two groups including treatment group (30 cases) and control group (30 cases) Lp(a) was determined by double digit point with filling ELISA divisor P selectin was detected by enzyme excessive clone antibody with filling divisor NO was measured by nitric acid revert enzyme colorimetry Blood grease was determined by double reagent immunity contrast chaotic divisor PLT was examined by corpuscle analysed appearance Results After the treatment, 18 cases were recovery and 9 cases showed apparent effect while 6 cases showed availability and 5 cases showed inefficacy in treatment group In control group, 7 cases were recovery and 11 cases showed apparent effect while 10 cases showed availability and 13 cases showed inefficacy There was a significant difference between two groups (χ 2 =3 86, P <0 05) There was a significant difference between control group and treatment group in PLT, Lp(a), membranous protein kinase(M PKC), P selectin and NO before treatment, whereas there was no significant difference after treatment There was a significant difference between before and after treatment in treatment group There was a significant difference between normal group and control group in PLT, Lp(a), M PKC, P selectin and NO before treatment There was no significant difference between before and after treatment in control group There was no significant difference between treatment group and control group before treatment There was a significant difference between treatment group and control group after treatment Conclusion The forepart thrombosis of sudden deafness partnering with hyperlipemia cause the worse diseases of sudden deafness which can be release by decreasing blood grease This treatment can increase the recovery rate of sudden deafness apparently更多还原