【摘要】 目的　探讨三组代谢型谷氨酸受体 (mGluRs)特异性拮抗或激动剂对弥漫性脑损伤(DBI)后损伤脑组织的神经保护作用。　方法　SD大鼠随机分为四组 ,在单纯DBI 1h后 ,脑室分别注射 10 μl第Ⅰ组mGluRs拮抗剂 (MCPG)、第Ⅱ组mGluRs激动剂 (DCG -Ⅳ )、第Ⅲ组mGluRs激动剂 (L -AP4)或等渗盐水 ,观察大鼠行为、皮层损伤神经元数及脑组织含水量变化。　结果　MCPG、DCG -Ⅳ及L -AP4均对大鼠DBI后死亡率无明显影响 (P <0 .0 5 )。MCPG和DCG -Ⅳ可明显改善大鼠DBI后行为学改变、降低皮层损伤神经元数量及脑组织含水量 ,以MCPG降低效果最为显著 (P <0 .0 5 ) ;而L -AP4则没有明显上述作用 (P >0 .0 5 )。　结论　第Ⅰ组mGluRs拮抗剂MCPG和第Ⅱ组mGluRs激动剂DCG -Ⅳ有一定的神经保护作用 ,其中MCPG作用最强更多还原

【Abstract】 Objective To study the neuroprotective effects of antagonist or agonist of metabotropic glutamate receptors (mGluRs) on diffuse brain injury (DBI) in rats. Methods All rats were randomly divided into four groups and injected intracerebro ventricularly with 10 μl of MCPG (GroupⅠ, antagonists), DCG Ⅳ (GroupⅡ, agonists) or L AP4 (Group Ⅲ, mGluRs) respectively 1 hour after DBI, while all control rats were injected with normal saline instead. Then, the motor and cognitive performance, the water content and the number of injured neurons were recorded at different intervals after DBI. Results There was no significant change in the mortality of rats with DBI after treatment with MCPG, DCG Ⅳ or L AP4. MCPG or DCG Ⅳ, especially MCPG could ameliorate the motor and cognitive performance and decrease water contents and the damaged neurons in the parietal cortex of the rats with DBI ( P <0.05). However, L AP4 did not have the effect above mentioned ( P >0.05). Conclusions MCPG and DCG Ⅳ, especially MCPG, have neuroprotective effects on DBI.更多还原