【摘要】 目的　 探讨急性胰腺炎时血液炎症介质水平与心脏损伤的关系。 方法　 用猫自身胆汁加去氧胆酸钠以高、低两种注射压力 ( 2 0kPa和 3kPa)经胰管逆行注入 ,诱发猫产生重、轻两型急性胰腺炎模型。观察血内皮素 - 1(ET - 1)、肿瘤坏死因子 -α(TNF -α)、磷脂酶A2 (PLA2 )、肌酸激酶同工酶 (CK -MB)含量变化及胰腺、心肌的病理改变。 结果 　两型急性胰腺炎ET - 1、TNF -α、PLA2水平明显高于对照组 (P <0 0 1)。各项指标重症组又明显高于轻症组 (P <0 0 1) ,ET - 1、TNF -α、PLA2水平与CK -MB的变化呈显著正相关 ,r分别为 0 816、0 6 96、0 6 6 8(P <0 0 1) ,并与急性胰腺炎致心脏病理改变相一致。 结论　ET - 1、TNF -α、PLA2可能参与了急性胰腺炎心脏损伤的发病过程。更多还原

【Abstract】 Objective To explore the effects of inflammatory mediators on heart damage in acute pancreatitis Methods The models of AP were made with the mixture solution(autologous bile mixtured with 30 mmol/L sodium deoxycholate,1∶1)being retrogradely injected into the pancreatic duct in different pressure.Twenty-eight mongrel cats were randomly divided into 3 groups:High pressure group(A,n=10),the injection pressure was 20 kPa for 5 minutes,then the pancreatic duct was ligated;Low pressure group(B,n=10),except with injection pressure 3 kPa,all other methods were the same as in A group;Control group(C,n=8):sham-operation,the pancreas was only moved aside.Blood endothelin-1(ET-1),tumor necrotizing factor-α(TNF-α),phospholipase A2(PLA2),creatine kinase isoenzyme(CK-MB)and histology of the pancreas and heart were observed after the models were made for 18h. Results The level of blood ET-1,PLA2,TNF-α increased significantly as compared with the control groupB( P<0 01 ),those in group A were higher than those in groupB( P<0 01 ).The levels of ET-1,TNF,PLA2 were positively related to CK-MB(r=0.816,0.696,0.668, P<0 01 ),and were associated with the degree of heart histologic alteration. Conclusion ET-1,TNF-α,PLA2 may take part in the process of heart damage in acute pancreatitis.更多还原