【摘要】 目的:探讨组织蛋白酶D(CD)、表皮生长因子受体(EGFR)、转移抑制基因nm23、抑癌基因p16在非小细胞肺癌(NSCLC)中表达的意义。方法:采用快速免疫组化法检测64例肺癌标本四种蛋白的表达。结果:肺癌组织CD、EGFR、nm23和p16表达的阳性率分别为65.6%、67.2%、60.9%和51.6%,p16蛋白表达缺失率达48.4%,CD和EGFR表达与肺癌患者临床分期(P<0.05,P<0.01)、淋巴结转移(P<0.01,P<0.05)密切相关。COX比例风险模型分析和Kaplan-Meier生存曲线分析显示CD和EGFR是影响肺癌患者预后的重要因素(P<0.05)。结论:在NSCLC中nm23、p16、CD和EGFR异常改变的频率很高,在NSCLC的发展中可能起促进作用。CD和EGFR可作为评价NSCLC患者的预后指标。更多还原

【Abstract】 Objective:To study clinical significance of the expression of cathepsin D(CD)?epidermal growth factor receptor(EGFR)?nm23and P16in patients with non-small cell lung can-cer.(NSCLC).Methods:A rapid immunohistochemical method was used to detecting the expression of four proteins the NSCLC patients in64caces lung cancer samples.Results:The positive expression rate of CD?EGFR?nm23?P16is65.6%?67.2%?60.9%and51.6%in the lung cancer tissues,respectively,deletion rate of P16protein expression was48.4%.Expression of CD?EGFR was significantly related to the stage of the disease(P<0.05,P<0.01)and lymph node metastasis(P<0.01,P<0.05)in the lung cancer patients.The multivariate analysis using COX hazard model and Kaplan-Meier method showed that CD and EGFR were the most important influence factors in prognosis of the disease.Conclusions:Abnormal expression of all the four factors are very high in the NSCLC patients,they may play promotion roles in development of NSCLC.CD and EGFR are the useful parameters to evaluate the prognosis of NSCLC.更多还原