【摘要】 目的:观察造血干细胞移植支持下的大剂量化疗对高危乳腺癌患者Th1、Th2类细胞因子(IFN-γ、IL-2,IL-10)的影响。方法:应用ELISA方法测定14例高危乳腺癌患者大剂量化疗前后血清IFN-γ、IL-2、IL-10的变化。结果:14例患者大剂量化疗前后血清中IFN-γ、IL-2、IL-10的水平分别为12.79±4.60pg/ml、6.55±5.42pg/ml、9.04±8.28pg/ml及12.38±3.23pg/ml、6.16±2.84pg/ml、9.00±6.85pg/ml,前后对比无统计学意义(P>0.05)。不同病理类型患者大剂量化疗前后血清细胞因子亦无显著差异(P>0.05)。转移淋巴结数大于50%与少于50%组相比,IL-10水平在大剂量化疗前两组有显著差异(P<0.05),但化疗后这种差异消失(P>0.05)。结论:大剂量化疗对Th1及Th2类细胞因子无影响,而对淋巴结转移数大于50%者的Th2类细胞因子有调节作用。更多还原

【Abstract】 Objective:To research the change of Th1and Th2cytokines following high-dose chemotherapy(HD)with stem cell rescue in patients with high-risk breast cancer.Meth-ods:The levels of serum IFN-γ,IL-2,IL-10in14patients with high-risk breast cancer were detected with ELISA method before and after high-dose chemotherapy.Results:The IFN-γ,IL-2,IL-10value in serum were respectively2.79±4.60pg /ml,6.55±5.42pg /ml,9.04±8.28pg /ml before HD and12.38±3.23pg /ml,6.16±2.84pg /ml,9.00±6.85pg /ml after HD,there were no significant difference of these cytokines changing(P>0.05).There were also no significant difference in dif-ferent pathologic patients.Compared the IL-10,however,between the metastasis lymph notes more than50%and less than50%group,there was significant difference before HD(5.25±2.94pg /ml vs14.08±10.62pg /ml P<0.05),but this difference was disappeared after HD(6.69±4.02pg /ml vs12.68±8.92pg /ml P>0.05).Conclusion:HD could not effect the Th1and Th2cytokines in this study group,but it could modulate the Th2cytokine(IL-10).更多还原