【摘要】 目的 探讨VEGF和nm23-H1在甲状腺肿瘤中的表达意义。方法 用免疫组化S-P法检测40例甲状腺良性病变、83例甲状腺癌中VEGF和nm23-H1的表达。结果 VEGF在正常甲状腺组织呈阴性表达,在甲状腺腺瘤、结节性甲状腺肿、甲状腺乳头状癌、滤泡癌、未分化癌表达阳性率分别为20.0％、26.7％、46.0％、60.0％和72.7％,与组织学类型密切相关(P<0.001);nm23-H1表达阳性率分别为80.0％、73.3％、61.5％、60.0％、45.6％,与组织学类型无相关性(P>0.05)。结论 VEGF是鉴别甲状腺良恶性肿瘤及判断其生物学行为的有效指标。更多还原

【Abstract】 Objective To study the expression of VEGF and nm23-Hl in thyroid carcinoma. Methods Immunohistochemistry was used to detect the expression of VEGF and nm23-Hl in 40 thyroid adenomas and 83 thyroid carcinomas. Results No positive expression of VEGF was found in normal thyroid tissues . The positite rate of VEGF and nm23Hl in thyroid adenomas .nodular goitre, papillary thyroid carcinoma, follicular thyroid carcinoma and undifferentiated carcinoma was 20. 0% ,26. 7% ,46. 0% ,60. 0% ,72. 7% and 80. 0% ,73.3% ,61.5% , 60.0% ,45.6% , respectively. The expression of VEGF was significantly correlated with different pathologic types of them( P < 0.001) , and there was no significant correlation of nm23-Hl with the pathologic types. Conclusion VEGF may be a good marker of degree of differentiation and behavior of thyroid neoplasms.更多还原