Objective To provide reference materials for clinical treatment of chronic fatigue syndrome (CFS). Methods The documents of treatment of CFS with acup-moxibustion and massage in the last 15 years are reviewed. In total, 22 papers are summarized from 4 aspects, differentiation and typing of syndromes, therapeutic methods, therapeutic courses and therapeutic effects. Conclusion Acup-moxibustion and massage therapy is effective with no side-effects, lower cost and safety for CFS.