【摘要】 目的 :研究替硝唑在大鼠小肠中的吸收情况。方法 :以pH8的磷酸盐缓冲液为溶剂 ,采用倍率系数法在 2 90 ,318nm处测定替硝唑 ;以 0 .1mol·L-1氢氧化钠为溶剂 ,以双波长法在 5 5 8,5 70nm处测定酚红。结果 :药物吸收符合一级动力学方程 ,平均吸收半衰期为 (2 .34± 0 .4)h ,最终吸收程度为 5 7.5 7%。结论 :本方法操作简便 ,结果准确可靠。更多还原

【Abstract】 OBJECTIVE To study tinidazole absorbed in rat small intestine.METHODS Tinidazole was determined by multiplication contant spectrophotometry at 290,318nm, which was carried out using pH 8 phosphate buffer. Phenol was determined by dual wavelength spectrophotometry at 558,570 nm, using 0.1 mol·L -1 NaOH as solvent.RESULTS Absorption of tinidazol was conicident with primary dynamics equation and the average elimiation half life was ( 2.3± 0.4) h. Ultimate absorption was 57.57%. CONCLUSIONS A simple, sensitive and selective method for the determination of tinidazol in rat small intestine.更多还原