【摘要】 目的　测定水不溶弱碱性药物氯雷他定的解离常数 ( pKb)。方法　采用Benet法和ChattenandHarris法。利用氯雷他定易溶于丙酮的性质 ,选用不同比例丙酮 水混合物为溶剂进行滴定 ,然后利用Benet法进行 pKb 的计算。结果　氯雷他定pKb 为 8.5 819,为弱碱性药物。结论　Benet法和ChattenandHarris法可有效测定难溶于水的弱碱性药物的 pKb。更多还原

【Abstract】 OBJECTIVE To determine the dissociation constant of loratadine which is an insoluble alkalescent drug.METHODS Different acetone water mixtures were used instead of water to titrate.The pK b was calculated by nonlogarithmic titration curves (Benet method).RESULTS The pK b of loratadine was 8.581 9.CONCLUSION The method can be used for the determination of dissociation constants of insoluble alkalescent drugs.更多还原