【摘要】 目的　筛选布洛芬分散片的处方及辅料用量。方法　将羧甲基淀粉钠、微晶纤微素按一定比例混合 ,作为片剂基本处方 ,以分散片的外观、崩解时限、体外溶出度及混悬性为指标进行处方筛选。结果　所筛选处方压制片剂外观光洁 ,在 40s内完全崩解 ,药物溶出快 ,并能通过 71 0 μm筛网。 结论　该分散片的质量主要与混合崩解剂的用量有关 ;混悬性主要与药物粒径大小有关 ,粒径越小 ,混悬性越好。更多还原

【Abstract】 OBJECTIVE To optimize the formulation of ibuprof en dispersible tablets and the amount of additions.METHODS Mix ing the CMS-Na and MCC in certain proportion as the basic formulation of the ta blets,the appearance,disintegration,dissolution and the suspensibility were inv estigated.RESULTS The tablets prepared were fine in appearan ce,disintegrated within 40 s,the suspension screened through the 710 μm mesh.CONCLUSION The quality of the dispersible tablets were mostly related to the amount of disinter grants.The smaller the powder size was ,the mo re stable the suspension was.更多还原