【摘要】 目的:探讨透明质酸(HA)、Ⅲ型前胶原肽、层粘蛋白及Ⅳ型胶原对各型肝炎肝纤维化的诊断意义。方法:应用酶联免疫吸附试验方法检测94例各型肝炎患者血清中的透明质酸、Ⅲ型前胶原肽、层粘蛋白及Ⅳ型胶原,结果应用x2检验及t检验进行统计学处理。结果:4项指标在慢性肝炎中、重度组和肝硬化组的检测结果均高于正常值且与相应对照组比较差异非常显著(p<0.01)。4项指标在各肝病组的平均阳性检出率随病情加重而逐渐升高、组间比较差异显著(P<0.05或P<0.01)。在慢性肝炎重度组和肝硬化组,以HA的检测数值和检出率为最高。结论:4项指标均可不同程度的反映肝脏的纤维化程度,可作为肝纤维化检测指标,而其中以HA更能反映肝硬化发展趋势。更多还原

【Abstract】 Objective: Our purpose was to study the significance of serum hyaluronic acid (HA) , precollagen Ⅲ N-terminal peptide, laminin, and type Ⅳ collagen for diagnosis of liver fibrosis in patients with various types of hepatitis and liver cirrhosis. Methods: Hyaluronic acid, procollagen Ⅲ N-terminal peptide, laminin, and type Ⅳ collagen were detected in serum of 94 patients with various types of liver diseases by ELISA. Data were analyzed statistically. Results: The levels of four markers in the groups of moderate, serious chronic hepatitis and liver cirrhosis were higher than that of the normal level. The differences were remarkable compared with the control group ( P <0. 01). The average positive rates of four markers increased gradually with the condition getting more serious , the difference were obvious between the groups ( P < 0.05 or P <0. 01). The level and positive rate of hyaluronic acid were all the highest in serious chronic hepatitis and cirrhosis group. Conclusion: These four markers may reflect the state of liver fibrosis in different liver diseases. Hyaluronic acid may be a useful marker for diagnosis of liver cirrhosis.更多还原