【摘要】 目的 :探讨血浆血栓调节蛋白 (TM)、蛋白C(PC)和蛋白S(PS)与慢性肝病的关系。方法 :用双抗体夹心ELISA法测定了 1 36例慢性乙型肝炎和 74例肝炎肝硬化患者血浆TM、PC和PS水平 ,并与 35名正常者进行对照分析。结果 :(1 )慢性乙型肝炎及肝炎肝硬化患者血浆TM水平均显著增高。 (2 )慢性乙型肝炎及肝炎肝硬化患者血浆PC、PS水平均显著降低 ,并与病情严重程度呈显著负相关。结论 :慢性乙型肝炎及肝炎肝硬化患者均存在肝窦内皮细胞损伤 ,且与凝血机制异常有关 ;检测血浆PC和PS可做为判断慢性肝病病情严重程度的指标更多还原

【Abstract】 Objective:To inuestigate the relationship between thrombomodulin(TM)?Protein C (PC)?protein S (PS) and chronic Liver disease,Methods:The plasm TM?PC and PS were detected by ELISA in 136 patients with chronic hepatitis B (CHB) and 74 patients with Liver cirrhosis(LC),the contrast analysis was performed,and then conpared with 35 normal cases.Results:(1)The plasma TM in CHB and LC were significantly higher than those in normal control.(2)The plasma PC and PS in CHB and LC were significantly lower than those in mormal control,and showed obviously negative correlation with the severity of patients condition.Conclusions:The patients with CHB and LC had endothelial cells injury of liver sinusoid and was related to abnormal blood coagulation mechanism;The decreased PC and PS can be used as markers to predict the severity of chronic liver disease.更多还原