【摘要】 目的设计合成 3 溴 4 硫色 (满 )酮类化合物 ,并对其抗真菌活性进行初步评价。方法以取代硫色 (满 )酮为原料 ,经溴化、氧化等反应制得目标化合物 ,化合物的体外抗真菌活性测定采用二倍浓度稀释法。结果共合成了 9个未见文献报道的新化合物 ,经红外光谱、核磁共振氢谱及元素分析确证其结构。其中化合物Ⅴb 的活性好于或相当于对照药。结论硫色 (满 )酮 3 位溴取代后具有较强的抗真菌活性。更多还原

【Abstract】 Aim To design and synthesize the 3-bromo-4-thiochrom(an)ones,and to value their antifungal activity. Methods BZ] The target compounds were prepared from the thiochromanones through bromination and oxidation,their antifungal effects were tested in vitro . Results Nine new compounds were synthesized.The structures of these compounds were confirmed by IR, 1H-NMR and elemental analyses.The compound The target compounds were prepared from the thiochromanones through bromination and oxidation,their antifungal effects were tested in vitro . Results Nine new compounds were synthesized.The structures of these compounds were confirmed by IR, 1H-NMR and elemental analyses.The compound Ⅴ_b exhibited excellent antifungal activity.Its MIC value was below or equal to that of the control. Conclusion The 3-bromo substituted thiochromanones show potent antifungal activity.更多还原