【摘要】 他克林是一个选择性较好但毒副作用明显的乙酰胆碱酯酶抑制剂。为了克服其不足 ,许多他克林衍生物和类似物都已被合成并进行了药理研究。从他克林的芳环、脂环和侧链氨基等 3个方面对他克林衍生物及类似物的合成和药理研究进行综述。更多还原

【Abstract】 Tacrine is a selective acetylcholinesterase(AChE)inhibitor which has serious liver toxicity.In order to overcome its drawbacks,many of tacrine analogues have been synthesized,and the pharmacological activities of some compounds have been studied.The synthesis and pharmacological effects of tacrine derivatives and their analogs were obtained from three main series:aromatic/saturated cyclic derivatives and the tacrine analogues have been systematically reviewed.更多还原