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4味中药对酪氨酸酶抑制作用的探讨

Study on the Inhibiting Effects of 14 Kinds of Chinese Materia Medica on Tyrosinase

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【作者】 闫军李昌生陈声利张君仁赵天恩

【Author】 YAN Jun,LI Changsheng,CHEN Shengli(Jinan City Hospital for Skin Diseases Prevention,Jinan 250001)ZHANG Junren(School of Pharmacy,Shandong University,Jinan 250012)ZHAO Tianen(Shandong Provincial Institute of Dermatology and Venereology,Jinan 250022)

【机构】 济南市皮肤病防治院山东大学药学院山东省皮肤病性病研究所 济南市250001济南市250001济南市250012济南市250022

【摘要】 目的 :研究14味中药对酪氨酸酶的抑制作用。方法:用50%乙醇提取中药有效成分 ,利用紫外分光光度法测定酶促反应的速度 ,以衡量其对酪氨酸酶的抑制作用。结果 :测得14条酶促反应时间曲线。结论 :13味中药对酪氨酸酶活性呈较好的抑制作用(P<0.01) ,除芦荟以外 ,其余中药不影响酶促反应的平衡。桃仁、僵蚕、芦荟抑制作用最好

【Abstract】 OBJECTIVE:To inverstigate the inhibitory effects of 14 kinds of traditional Chinese medicines on tyrosinase activity METHODS:The effective components of traditional Chinese medicines were extracted by 50% ethanol The speed of enzymic catalysis of tyrosinase was determined by ultraviolet spectrophotometry to evaluate the inhibitory effects of extracts of traditional Chinese medicines RESULTS:14 reactive time curves of enzymic catalysis of tyrosinase were obtained CONCLUS_ION:13 kinds of traditional Chinese medicines in vitro showed a better inhibitive effect on tyrosinase activity(P<0 01), without influence on the equilibrium of enzymic catalysis except Aloe barbadensis Miller Prunus persica Batsch,Bombyx mori Linnaeus and Aloe barbadensis Miller showed the best inhibitory effect on tyrosinase activity

  • 【分类号】R285
  • 【被引频次】14
  • 【下载频次】301
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