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盐酸乌拉地尔(利喜定)注射液与临床常用5种药物的配伍稳定性考察
Study on the Stability of Urapidil Injection Mixing With Five Commonly-used Drugs
【摘要】 目的 :考察盐酸乌拉地尔注射液分别与氯化钾、门冬氨酸钾镁、碳酸氢钠、维生素C、盐酸利多卡因5种注射液的配伍稳定性。方法 :采用紫外分光光度法考察各配伍液在室温条件下 (15℃~25℃ )配伍0h~8h内吸收度、吸收曲线变化 ,测定 pH值 ,同时观察其外观和普通显微镜下的变化。结果 :盐酸乌拉地尔注射液在10 %葡萄糖输液中分别与以上5种注射液混合配伍后 ,pH值、外观、普通显微镜下及紫外吸收光谱各项检查均无变化。结论 :盐酸乌拉地尔注射液分别与以上5种注射液配伍稳定。
【Abstract】 OBJECTIVE:To study the stability of Urapidil injection separately mixing with KCl injection,potassium magˉnesium-L-aspartate injection,NaHCO 3 injection,vitamine C injection and lidocaine injection in10%glucose injecˉtion.METHODS:Ultraviolet spectrophotometry was used for detecting the changes of absorbance,absorption curve,and pH at15℃~25℃within0~8hours,and the external appearance and changes under light microscope were observed.RESULTS:There were no evident changes in absorbance,absorption curve,external appearance,microscopic findings and pH.CONCLUSION:Urapidil injection is stable in mixing with above-mentioned5drugs in10%glucose solution.
- 【文献出处】 中国药房 ,China Pharmacy , 编辑部邮箱 ,2003年05期
- 【分类号】R942
- 【被引频次】3
- 【下载频次】130