【摘要】 为了研究CD34+ CD1 1b+ 细胞输入量在脐血移植中对中性粒细胞和血小板恢复时间的影响 ,观察并分析 1 7例儿童急性白血病患者进行无关脐血移植的临床数据。结果显示 ,移植后 1 7例患者中性粒细胞≥ 0 5× 1 0 9 L的时间为 1 1～ 32天 (中位数为 1 7天 ) ;血小板≥ 2 0× 1 0 9 L的时间为 1 2～ 1 1 8天 (中位数为 4 0天 )。CD34+CD1 1b+ 细胞输入量为 1 0 7～ 79 0 0× 1 0 4 Kg(中位数为 9 1 8× 1 0 4 Kg)。CD34+CD1 1b+ 细胞输入量与中性粒细胞恢复时间呈反比 (γ =- 0 4 89,P <0 0 5) ;CD34+CD1 1b+ 细胞输入量与血小板恢复时间无关 (r =- 0 2 38,P >0 0 5)。CD34+ CD1 1b+细胞输入量与造血干细胞移植时的造血重建有关。更多还原

【Abstract】 To study whether the number of CD34 + CD11b + cells reinfused affect the recovery of neutrophil and platelet after umbilical cord blood transplantation for the treatment of childhood acute leukemia, the clinical data of 17 children cases with acute leukemia treated by unrelated umbilical cord blood transplantation were observed Results showed that, the time to reach an absolute neutrophil count of ≥0 5×10 9/L ranged form 11 to 32 days, with medians of 17 days of all the patients The time to reach a platelet count of ≥20×10 9/L ranged from 12 to 118 days (media, 40 days) The number of CD34 + CD11b + cells in cord blood after freeze thawing was 1 07～79 00×10 4/kg (media, 9 18×10 4/kg) There had the tendency of association between the number of CD34 + CD11b + cells reinfused and the time to neutrophil recovery (γ=-0 489, P <0 05) It was concluded that the number of CD34 + CD11b + cells reinfused is involved in hematopoietic engrafment after umbilical cord blood transplantation更多还原