【摘要】 目的　观察麻醉与手术创伤对不同月龄大鼠认知功能的影响 ,探讨麻醉与术后认知功能障碍的机制。方法　将不同月龄的大鼠分别分为正常组、麻醉组和麻醉 +手术组 ,于不同时间分别进行Y型迷宫学习记忆能力测试及旷场分析实验。结果　麻醉或麻醉手术后 1天 ,高龄鼠与正常自身对照Y型迷宫和旷场分析实验均有显著差异 (Y型迷宫 P <0 .0 1,旷场分析实验P <0 .0 1)。麻醉或术后 1天低龄鼠与正常自身对照旷场分析实验有显著差异 (P <0 .0 5 )。结论　麻醉与手术创伤对大鼠认知功能的影响是暂时性的 ,可逆性变化 ,随着时间推迟 ,以后恢复。更多还原

【Abstract】 Objective To evaluate the effects of pentobarbital sodium and operation on postoperative cognitive function between the young rat and the old-age rat and explore the mechanism of post-operation cognitive disorder . Methods All rats were randomly divided into three groups(1) The control group.(2) The anesthesia group(3)The anesthesia + operation group. Y-maze and open field test was performed before and at 1 ?3? 7 and 30ds after anesthesia or operation .Results In comparing with the normal control group, Open-field scores decreased significantly at 1 day after anesthesia or operation in both young groups and old-age groups (young groups P <0.05,old-age groups P <0.01). And Y-maze scores decreased significantly in old-age groups ( P <0.01).Conclusion The postoperative cognitive dysfunction may be a transient and reversible condition. With the time gone, the cognition function similarly recovered in the other time.更多还原