【摘要】 目的 :研究慢性心力衰竭和急性冠状动脉综合征患者肿瘤坏死因子 α (TNF α)、白细胞介素 6(IL 6)释放部位的区别。　　方法 :选取接受心导管检查及治疗的 60例患者 ,按疾病类型分为三组 ,急性冠状动脉综合征 17例 (急性冠状动脉综合征组 ) ,慢性心力衰竭 15例 (慢性心力衰竭组 ) ,另 2 8例为对照组。分别自股动脉、股静脉、冠状动脉左主干和冠状静脉窦 4处取血 ,比较各部位TNF α、IL 6水平的差异。　　结果 :①慢性心力衰竭组和急性冠状动脉综合征组各部位TNF α、IL 6水平均高于对照组 (P <0 0 1) ;②急性冠状动脉综合征组冠状静脉窦TNF α、IL 6水平高于左主干 ,而慢性心力衰竭组和对照组无此现象。　　结论 :慢性心力衰竭炎性因子主要来源于心外低灌注组织 ;急性冠状动脉综合征患者中心内组织炎性细胞因子水平明显升高。更多还原

【Abstract】 Objective:To study the different sites of tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6) release in congestive heart failure(CHF)and acute coronary syndrome(ACS). Methods:Sixty patients undergoing cardiac catheterization were recruited.Blood samples were obtained from the femoral artery,femoral vein,main left coronary artery(MLCA)and coronary sinus(CS).TNF-α and IL-6 were measured in the different 4 sites. Results:①The levels of TNF-α and IL-6 obtained from the 4 sampling sites in CHF and ACS were higher than those in the control group;②The TNF-α and IL-6 levels of CS were higher in the ACS group than those of MLCA group,but the phenomina were not found in the CHF and control groups. Conclusion:Elevated inflammatory cytokine levels in the CHF group may result from extracardiac tissues.Intracardial inflammatory cytokine levels in the ACS group were significantly greater than those of the other groups.更多还原