【摘要】 目的 :检测未经治疗梅毒患者外周血淋巴细胞亚群 ,并探讨其临床意义。方法 :应用流式细胞仪检测 36例 HIV阴性未经治疗的二期及隐性梅毒患者外周血淋巴细胞亚群及 NK淋巴细胞 ,并与 30例健康人群的检测结果相对照。结果 :患者 CD3、CD4 及 NK淋巴细胞与健康人群的检测结果相比差异均无显著性 (P>0 .0 5 ) ,而患者 CD8淋巴细胞明显高于对照组 ,差异有非常显著性 (P<0 .0 0 1) ,CD4 / CD8的比率明显低于对照组 ,差异有非常显著性 (P<0 .0 0 1) ;RPR滴度为 1∶ 2～ 1∶ 8的梅毒患者 CD3淋巴细胞的比例高于对照组 ,差异有显著性 (P<0 .0 5 ) ;二期与隐性梅毒患者之间以及不同 RPR滴度梅毒患者之间 T淋巴细胞亚群及 NK淋巴细胞差异均无显著性 (P>0 .0 5 )。结论 :未经治疗的梅毒患者外周血存在细胞免疫不平衡 ,CD8明显升高可能降低机体抵抗和清除梅毒螺旋体感染的能力。更多还原

【Abstract】 Objective: To detect the lymphocyte subsets of peripheral blood in untrated syphilitic patients and to investigate its clinical significance.Methods:Lymphocyte subsets and NK cell of peripheral blood were measured with flow cytometry（FCM） in 36 untreated syphilitic patients with flow cytometry（FCM）in 36 untrated syphilitic patients with human immunodeficiency virus seronegative.Results:The results revealed that CD₃,CD₄ and NK cells showed no significantly differences between patients and the controls （ P >0.05）.CD₈ in patients was significantly higher than those in the controls（ P <0.001）;Consequently,the CD₄/CD₈ ratio was significantly decreased.CD₃ in patients with RPR from 1∶2 to 1∶8 was higher than those in the controls （ P <0.05）;The lymphocyte subsets and NK revealed no significantly differences between untreated secondary and latent syphilitic patients （ P >0.05）.Conclusion:These findings suggests that there is an inbalance for cellular immunity in the peripheral blood of untreated syphilitic patients and the significantly elevated CD₈ may weaken the ability of resistance and clearing Treponema pallidum infection.更多还原