【摘要】 目的　探讨母血白细胞介素 6(IL -6)与早产亚临床绒毛膜羊膜炎及早产儿预后的关系。方法　用酶联免疫吸附实验测定 67例早产孕妇及 3 2例相同孕周正常孕妇血IL -6,分娩时取部分胎盘胎膜送病检 ,记录 1周内早产儿情况。结果　早产组血IL -6、WBC明显高于对照组 (P <0 0 5 ) ,组织学绒毛膜羊膜炎阳性组血清IL -6、C -反应蛋白 (CRP)均明显高于组织学绒毛膜羊膜炎阴性组 (P <0 0 1)。母血IL -6≥ 10ng/L比IL -6<10ng/L有较高的组织学绒毛膜羊膜炎和明显的新生儿发病率。结论　母血IL -6是预测早产亚临床绒毛膜羊膜炎及早产明显的新生儿发病率一项有用的指标更多还原

【Abstract】 Objective To investigate the relationship between maternal serum interleukin-6 (IL-6) and subclinical chorioamnionitis and the early outcome of premature infants.Methods Serum IL-6 in 67 cases of preterm labour and 32 cases of normal pregnancy at 28～36 gestational weeks were measured by enzyme linked immunosorbert assay (ELISA).The placenta were detected after labour,and recorded the neonatal outcome within one week.Results The level of serum IL-6 and WBC in preterm group were significantly higher than that in control.The group with histological chorioamnionitis showed a significant increase in serum IL-6?CRP,compared with that without chorioamnionitis.Patients with serum IL-6≥10ng/L had higher histological chorioamnionitis and significant neonatal morbidity than those with serum IL-6<10ng/L.Conclusion Maternal serum IL-6 is more useful markers for detection of subclinical chorioamnionitis and the early outcome of preterm infants.更多还原