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谷氨酰胺颗粒剂在健康人体的药代动力学研究
The Pharmacokinetics Study of Glutamine Granules in Healthy Volunteers
【摘要】 目的了解口服谷氨酰胺颗粒剂的药代动力学改变。方法获得知情同意的健康志愿者8名,口服谷氨酰胺0.25g·kg-1,用高效液相测定法测定外周血0(服药前)、0.5、0.75、1.0、1.25、1.5、2.0、2.5、3.0、4.0h每个时间的谷氨酰胺浓度。结果健康人空腹时谷氨酰胺浓度为(592±86)μmol·L-1,口服谷氨酰胺0.25g·kg-1后,(45~75)min出现峰值,峰浓度为(2113±303)μmol·L-1,减去原始浓度,药物的峰浓度为(1521±312)μmol·L-1,150min后平稳降至正常范围,药物半衰期(T1/2)为(67±13)min。结论口服谷氨酰胺颗粒剂机体吸收较好,代谢快,生物利用度较高。
【Abstract】 Objectives To investigate pharmacokinetics of glutamine granules after oral adminitration.Methods 8consented healthy volunteers were enrolled with oral administration of glutamine granules0.25g·kg -1 ,the concentrations of serum glutamine were measured by high performance liquid chromatology,the blood samples were collected at0(before oral administration),0.5,0.75,1.0,1.25,1.5,2.0,2.5,3.0,and4.0h.Results The baseline serum glutamine were(592±86)μmol·L -1 .After(45~75)min,the concentration of serum glutamine increased to the peak value of(2113±303)μmol·L -1 ,subtracted by the original concentration,the serum peak glutamine concentration was(1521±312)mmol·L -1 ;after150min,it was decreased steadily to the normal range,the elimination half-life(T 1/2 )was(67±13)min.Conclusions Orally administrated glutamine granules were absorbed well with rapid metabolism and high bioavailability.
- 【文献出处】 中国临床营养杂志 ,Chinese Journal of Clinical Nutrition , 编辑部邮箱 ,2003年02期
- 【分类号】R969.1
- 【被引频次】17
- 【下载频次】242