【摘要】 2 0 0 0年 10～ 11月 ,上海市杨浦区某幼儿园发生手足口病流行 ,采集了 2 5例粪便标本分离病毒 ,用RD细胞分离出肠道病毒 (EV) ,经用标准血清鉴定为EV71型 13株 ,埃可病毒 13型 (ECHO13 ) 1株 ,EV71型分离率为 5 2 %。病人血清与EV71型分离株的中和抗体滴度较高 ,多数 >1∶2 5 6 ,而与柯萨奇病毒A组 16型 (Cox .A16)的中和试验滴度多数 <1∶2。 5例双份血清有 1例EV71型抗体呈 4倍升高 ,而Cox .A16型均无 4倍升高 ,表明本次流行由EV71型引起。更多还原

【Abstract】 In Oct-Nov.2000,there occurred a hand-foot-and-mouth disease(HFMD)epidemics in a kindergarden of Yangpu District of Shanghai.Thirteen strains of enterovirus type 71(EV71) and one strain of ECHO 13 were isolated from 25 fecal specimens on RD cell line.The isolation rate of EV71 was 52.00%.The serum neutralizing antibody titers against EV71 in HFMD patients were >1∶256,and that of CoxA 16 were<1∶2.One of five paired-sera of the patients showed 4-fold rising of antibody against EV71,while there was no such result of CoxA 16 .The data above indicated that the HFMD epidemic in kindergarden was caused by EV71.更多还原