【摘要】 目的　探讨慢性肝病患者血清铁蛋白 (SF) ,血清纤维化指标 [血清透明质酸 (HA) ,Ⅲ型前胶原 (PCⅢ ) ,IV型胶原 (IV -C) ,层粘蛋白 (LN) ]与肝纤维化的关系及临床诊断价值。方法　对 69例慢性肝病患者 ,用放射免疫法测得血清SF ,HA ,PCⅢ ,IV -C ,LN ,并对其中 50例进行肝穿标本病理组织学检查 ,作肝纤维化程度分期。结果　69例慢性肝病患者SF与HA、PCⅢ、IV -C、LN含量依病情发展有一定的正相关 ,r分别为 0 452 ,0 3 0 6,0 3 18,0 3 2 4,SF含量随肝纤维化程度逐期增高 ,r =0 656。结论　血清铁蛋白及血清纤维化指标对肝纤维化的诊断有较大指导作用 ,但对某一患者评价这些指标的意义时 ,应结合肝功能检查、B超检查、肝活检及临床表现做全面分析更多还原

【Abstract】 Objective To find the relationship between serum levels o f serum ferritin(SF),hyaluronic acid(HA),type Ⅲ procollage(PCⅢ),laminin(LN),t ype Ⅳ collagen(IV-C) and heaptic fibrosis in patients with chronic liver diseas e as well as to determine their value in clinical practice.Methods 69 serum samples from patients with chronic liver disease were tested with RIA for serum ferritin and fibrosis indexes assays inc luding HA,LN,PCⅢ and IV-C.50 of the patients with serum samples performed liver biopsy and the biopsy material were examined pathomorphologically.Ser um ferritin and fibrosis were compared according to fibrosis stage.Results In the 69 serum samples from patients with chroni c liver disease,the concentration of serum ferritin had significant correlation with the levels of fibrosis indexes due to the increase of degree of chronic liv er disease.The relation indexes to HA,PCⅢ,LN and IV-C were 0.452,0.306,0.318,0. 324 respectively.The levels of serum ferritin were elevated due to increase of h epatic fibrosis stages(from S1 to S4).The relation indexes to the degree of hepa tic fibrosis(S) is 0.656.Conclusion Serum ferritin and serum fibrosis indexes play an important indicative role in diagnosing hepatic fibrosis degree.However,as d iagnosis markers they should be combined with liver function ultrasonography liv er pathological diagnosis and clinical features.更多还原