【摘要】 目的 研究中成药制剂韦氏活骨Ⅰ号胶囊治疗家兔股骨头缺血性坏死的作用机理。方法成年健康家兔36只,采用液氮冷冻的方法制备家兔双侧股骨头缺血性坏死的动物模型,随机分为实验组及对照组,术后均以普通饲料喂养,实验组同时灌韦氏活骨Ⅰ号胶囊制成的悬浮液。分别于术后6、12和20周处死家兔,观察各项实验指标。结果 实验组血清AKPase、骨密度均较对照组明显升高,股骨头大体形态、光镜及X线片显示出实验组骨坏死于其某一较早期阶段中止并出现修复迹象,组织结构观察表明实验组股骨头组织结构较对照组致密规则。结论 韦氏活骨Ⅰ号胶囊可以改善局部血液循环,加速新骨生成,是治疗骨坏死的有效药物。更多还原

【Abstract】 Objective To study the mechanism of Weishi Huogu Capsule No Ⅰ(WHI)(Chinese herbal medicine) for the treatment of avascular necrosis of the femoral head in rabbits. Methods The models of bilateral avascular necrosis of the femoral head were produced in 36 healthy rabbits by using freezing method with liquid nitrogen. All the rabbits were randomly divided into two groups:experimental group and the control. The rabbits in control group were fed with common food and those in experimental group were added WHI suspension. They were sacrificed at 6th, 12th and 20th weeks after operation and the content of AKPase in serum, the bone density of hip region were determined. Radiographic and optical microscopic examination were also done in this study. Results The content of AKPase in serum and the bone density of hip region of rabbits in experimental group were much higher than those of control group. The radiographic and optical microscopic examination showed that in experimental group,osteonecrosis was discontinued at some early stage and bone repair can be observed. The constitution of femoral head in experimental group was more dense and regular than that of control group. Conclusion WHI is effective in improving local blood circulation,accelerating new osteogenesis, and it is an effective drug for the treatment of avascular necrosis of the femoral head.更多还原