【摘要】 目的 :评价高强度聚焦超声 (high intensity focused ultrasound,HIFU)治疗兔乳腺移植性肿瘤的疗效。方法 :30只 VX2 兔乳腺移植性肿瘤于肿瘤移植后 1 1天随机分为治疗组 1 0只 ,手术组 1 0只 ,对照组 1 0只。治疗组接受频率 1 .6MHz,声强 1 1 50 0 W· cm-2的 HIFU覆盖治疗 ,手术组接受常规手术切除局部肿瘤 ,对照组接受假照治疗。治疗后观察 8月 ,观察动物的平均存活时间、8月存活率及肿瘤的生长和转移情况。结果 :治疗组和手术组平均存活时间和 8月存活率分别为 1 90 .6± 79.8天和 1 74.4± 87.7天 ,70 %和 60 % ,无显著性差异 (P>0 .0 5) ,均明显高于对照组 (62 .2± 1 8.2天和 0 ,P<0 .0 5) ;治疗组和手术组的肿瘤转移率分别为 2 0 %和 30 % ,无显著性差异 (P>0 .0 5) ,均明显低于对照组 (1 0 0 % ,P<0 .0 5)。结论 :HIFU能有效地治疗兔乳腺移植性肿瘤 ,延长动物的存活时间 ,降低肿瘤复发率和转移率 ,取得与手术治疗相似的疗效 ,为今后开展 HIFU治疗乳腺癌的临床研究提供实验依据。更多还原

【Abstract】 Objective:To evaluate the effectiveness of high intensity focused ultrasound(HIFU) for the treatment of implanted rabbit breast tumor.Methods:Thirty rabbits were randomly divided into three groups 11 days after tumor implantation: HIFU treatment groupc (10), surgery group (10),control group (10) and HIFU ablation with frequency 1 6MHz and intensity 11500W·cm -2 was completely performed to treatment group Lumpectomy was performed in surgery group at the same time The animals in control group underwent pseudo-irradiation The observation period was 8 months The survival time survival rates of all animals, the growth and metastasis of tumors were observed after HIFU ablation.Results:The animals’ average survival time and survival rate of HIFU treatment group and surgery group were 190 6±79 8 days and 174 4±87 7 days,70% and 60% respectively.There were no significant differences from each other( P >0 05),but significant differences between the HIFU group from those of the control group (62 2±18 2 days,0, P <0 05) The metastatic rate of HIFU treatment group and surgery group were 20% and 30% respectively.There were no significant differences from each other ( P >0 05),but significant differences from those of control group(100%, P <0 05).Conclusions:HIFU can precisely and effectively destroy the implanted rabbit breast tumor,prolong the survival time of the animals It can decrease the recurrent rate and metastatic rate of the tumor and achieve the same effect as surgery This provides experimental basis for clinical study on HIFU for the treatment of breast carcinoma.更多还原