【摘要】 目的 :探讨血清VEGF对肝癌栓塞化疗疗效的影响。方法 :分析 30例肝细胞肝癌患者的血管造影 ,并采用ELISA检测 2 0例TACE前后患者血清VEGF的变化。结果 :1 3例肿瘤富血管患者血清VEGF水平高于 1 7例肿瘤乏血管患者 (8 80± 3 2 3ng/mlvs 5 70± 2 .68ng/ml,P <0 0 5) ;患者肝动脉栓塞治疗前后血清VEGF分别为 7 41± 3 56ng/ml,8 72± 3 79ng/ml,P <0 0 5。有 1 6例患者血清VEGF水平在肝动脉栓塞治疗后升高 ,其中 1 2例在第二次血管造影时发现新生肿瘤血管 ,他们的血清VEGF水平显著升高达 1 0 84± 2 70ng/ml。血清VEGF浓度升高的患者介入的临床疗效较差。结论 :肝癌TACE后若肿瘤细胞表达VEGF增强 ,其预后差 ,血清VEGF是影响肝癌栓塞化疗效果的因素之一更多还原

【Abstract】 Purpose:To determine the effect of serum expression VEGF in TACE of hepatocellular carcinoma. Methods:We examined tumor blood vessels of 30 patients with HCC by angiography and measured serum VEGF concentrations by ELISA.Results:We found serum VEGF concentrations in hypervascular patients were higher than in hypovascular patients (8.80±3.23 ng/ml vs 5.70±2.68 ng/ml, P <0 05). Serum VEGF concentrations in 20 patients rose after TACE(7 41±3 56 ng/ml,8 72±3 72 ng/ml, P <0 05),especially the patients with neovascularization detected by secondery angiography (10 84±2 70 ng/ml). The prognosis of the patients with rising VEGF concetrations was dismal. Conclusions:TACE of hepatocellular carcinoma can induce VEGF expression which may limit the ability of chemoembolization to eliminate cancer cells.更多还原