【摘要】 目的　研究难治性癫痫与血清谷氨酸脱羧酶抗体 (GAD-A)水平的关系 ,探讨难治性癫痫的发病机制。方法　应用酶联免疫吸附法 (EL ISA)测定了 3 0例难治性癫痫和 3 0例完全缓解的癫痫患者血清 GAD-A水平。结果　难治性癫痫患者和完全缓解癫痫患者血清 GAD-A水平无显著性差异 (P>0 .0 5) ,并且 ,各种类型癫痫患者其 GAD-A亦无明显差异 (P>0 .0 5)。结论　 GAD-A与难治性癫痫无明确的相关性 ,需要进一步扩大规模研究难治性癫痫中的谷氨酸脱羧酶抗体的变化更多还原

【Abstract】 Objective To study the relationship between the le ve ls of autoantibodies to glutamic acid decarboxylase (GAD-A) and intractable epi lepsy in order to explore the pathogenic mechanisms of intractable epilepsy.Methods The authors investigated the prevalence of GAD-A in patien ts with intractable epilepsy (n=30) and controlled epilepsy (n=30) by en zyme-linked immunosorbent assay(ELISA).Results There was no si gnificant difference in the levels of GAD-A between patients with intractable a nd controlled epilepsy.Among the different seizure types,there was no significan t difference either.Conclusion There is no significant relatio nship between GAD-A and intractable epilepsy.Larger scale studies,perhaps compa ring different epilepsy syndromes,are required to determine the exact clinical r ole of GAD-A in intractable epilepsy.更多还原