【摘要】 目的 观察凋亡调节蛋白的表达与脑膜瘤级别和复发的关系。方法 用LSAB免疫组织化学方法对80例脑膜瘤细胞中凋亡调节蛋白Bcl-2、Bax、Bcl-XL的表达进行分析。结果 恶性组Bcl-2瘤蛋白阳性率(88％)明显高于良性组(37％,P<0.05)。分别比较良性组、非典型组、恶性组中Bax、Bcl-xL癌蛋白表达阳性率,无显著性差异(P>0.05)。而Bel-2+Bcl-XL/Bax与脑膜瘤级别有统计学相关性(P<0.01)。非复发组、复发组首次手术组、再次复发组中Bcl-2、Bax、Bcl-XL癌蛋白阳性率两两比较均无显著性差异(P>0.05)。结论 Bcl-2、Bax、Bcl-XL在脑膜瘤发生中起调节作用,Bcl-2+Bcl-XL/Bax是脑膜瘤生物学行为的有效检测法。更多还原

【Abstract】 Objective To explore the relationship between expression of apoptosis-modulating proteins and histopathological grade and recurrence in meningioma.Methods Immunohistochemistry method (LSAB) was used to detect the expression of Bcl-2 , Bax and Bcl-XL in 80 cases of meningioma including benign group (38 cases) , atypical group (26 cases) and malignant group (16 cases).Results Expression of Bcl-2 oncoprotein positive in 88% cases in malignant group was significantly higher than that of benign group (37%,P<0.05). There was no significant difference in the expression positive rate of Bax, Bcl-XL oncoprotein among benign, atypical and maligant groups (P>0.05) , but Bcl-2+Bcl-XL/Bax was associated statistically with meningioma grade (P<0. 01) . There was no significant difference in the compare expression of Bcl-2, Bax, Bcl-XL oncoprotein positive in non-recurrent, initially resected recurrent and recurrent meningiomas (P>0.05).Conclusion Bcl-2, Bax and Bcl-XL might play important roles in meningiomas and BCL-2+BCL-XL/Bax is useful parameters for estimation of biological behavior of meningiomas.更多还原